| Cat. No. |
Product Name |
Information |
| PC-38148 |
Alobresib
BET inhibitor
|
GS-5829 (GS5829, Alobresib) is a novel potent, selective BET inhibitor. |
| PC-38071 |
GSK778
BRD BD1 inhibitor
|
GSK778 is a potent and selective inhibitor of bromodomain (BRD) BD1 with IC50 of 75 nM (BRD2-BD1), 41 nM (BRD3-BD1), 41 nM (BRD4 BD1), and 143 nM (BRDT BD1), respectively. |
| PC-38064 |
ODM-207
pan-BET inhibitor
|
ODM-207 (ODM207) is a highly potent, selective and orally active pan-BET inhibitor with potent and broad antiproliferative effects. |
| PC-38040 |
Trotabresib
BET inhibitor
|
Trotabresib (CC90010) is a reversible and orally active BET bromodomain inhibitor, shows significant antiproliferative activity in glioblastoma cells and patient-derived xenograft models as monotherapy and in combination with temozolomide (TMZ). |
| PC-35931 |
Bromotriazine
BET inhibitor
|
Bromotriazine (BTZ) is a covalent probe against bromodomain containing proteins with selectively targeting
non-catalytic, highly conserved amino acid residues.. |
| PC-35848 |
TP-238
|
TP-238 (TP238) is a CECR2/BPTF bromodomains chemical probe with IC50 of 30 nM against CECR2 and 350 nM against BPTF in an alphascreen assay, KD of 10 nM for CECR2 and 120nM for BPTF in ITC assays. |
| PC-35750 |
CN750
BRD4 inhibitor
|
CN750 (CN-750) is novel BRD4 (BD1, 2) inhibitor with IC50 of 44 nM, MV4-11 IC50 of 0.54 uM. |
| PC-35749 |
CN427
BRD4 inhibitor
|
CN427 (CN-427) is a a novel potent BRD4 (BD1, 2) inhibitor with IC50 of 66 nM, MV4-11 viability IC50 of 1.1 uM. |
| PC-35746 |
BRM014
BRG1/BRM inhibitor
|
BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both. |
| PC-35710 |
SGC-iMLLT
YEATS inhibitor
|
SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1). |
| PC-35709 |
GNE-371
TAF1(2) inhibitor
|
GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members. |
| PC-35692 |
BRD4 inhibitor Compound V
|
BRD4 inhibitor Compound V is a domain-selective inhibitor of BRD4 with IC50 of 1.8 uM for BRD4 BD1, displays 6- and 16-fold selectivity for BRD4 over BRD2 and BRD3, respectively. |
