| Cat. No. |
Product Name |
Information |
| PC-72676 |
UM-002
BRD4 inhibitor
|
UM-002 is a highly potent, selective, brain penetrant BRD4 bromodomain inhibitor with IC50 of 8.8 and 2.4 nM for BRD4-1 and BRD4-2, respectively. |
| PC-72646 |
I-BET567
pan-BET inhibitor
|
I-BET567 (GSK3383567) is a potent, oral pan-BET inhibitor with Ki of 5-40 nM against BD1/ BD2 of BRD2/3/4/BRDT. |
| PC-72573 |
SR-0813
ENL/AF9 YEATS inhibitor
|
SR-0813 (SR0813) is a potent, selective, dual ENL/AF9 YEATS domain inhibitor (IC50 =25/311 nM). |
| PC-72564 |
CDD-1102
BRDT BD2 inhibitor
|
CDD-1102 (CDD1102) is a potent, selective second bromodomain (BD2) of BRDT and BRD4 inhibitor with IC50 of 7 and 25 nM, >1,000-fold and 300-fold selectivity over BRDT-BD1 and BRD4-BD1. |
| PC-72470 |
GSK789
BET BD1 inhibitor
|
GSK789 (GSK-789) is a potent, cell-permeable, and highly selective inhibitor of the first bromodomains (BD1) of the BET family with IC50 of 20 nM BRD4 BD1, 1500-fold selectivity over BD2. |
| PC-72321 |
BRD8 inhibitor DN02
BRD8 inhibitor
|
BRD8 inhibitor DN02 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 48 nM, and Kd of 34 nM. |
| PC-72261 |
BRD4 D1 inhibitor 30
BRD4 D1 inhibitor
|
BRD4 D1 inhibitor 30 is a high-affinity, BRD4 D1-selective chemical probe with Kd of 18 nM, 500-fold selectivity against BRD2 D1 and BRD4 D2. |
| PC-72188 |
BY27
BET BD2 inhibitor
|
BY27 (BD2 inhibitor BY27) is a potent, highly selective BET BD2 inhibitor with Ki of 8.9/8.2/14.2 nM for BRD2/3/4-BD2 respectively. |
| PC-72187 |
SJ432
BET BD2 inhibitor
|
SJ432 (SJ-432) is a potent, highly selective BET BD2 inhibitor with Kd of 6/2 nM (BRD2-BD2/BRD4-BD2), displays 80/152-fold selectivity over BD1, respectively. |
| PC-72186 |
SJ018
BET BD2 inhibitor
|
SJ018 (SJ-018) is a potent, highly selective BET BD2 inhibitor with KD of 14 nM (BRD2-BD2), 67-fold selectivity over BRD2-BD1. |
| PC-72185 |
GSK737
BET BD2 inhibitor
|
GSK737 (GSK-737) is a potent, highly selective BET BD2 inhibitor with pIC50 of 7.3 (BRD4 BD2), 200-fold selectivity over BRD4 BD1. |
| PC-72184 |
GSK217
BET BD2 inhibitor
|
GSK217 (GSK-217) is a potent, highly selective BET BD2 inhibitor with pIC50 of 7.5 (BRD4 BD2), 300-fold selectivity over BRD4 BD1. |
