BRD8 inhibitor DN01

Chemical Structure : BRD8 inhibitor DN01

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货号: PC-38761Not For Human Use, Lab Use Only.

BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

BRD8 inhibitor DN01 is a first-in-class selective and cellularly active probe for NuA4 factor BRD8 (BD1) with AlphaScreen IC50 of 12 nM, displays IC50 of 0.21 uM in-cell engagement within BRET displacement assays, shows no affinity for BRD8 (BD2), CBP, and p300.

物理化学性质&存储条件

分子量	370.424
分子式	C21H23FN2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-(4-((dimethylamino)methyl)-2,6-dimethoxyphenyl)-7-fluoro-2-methylisoquinolin-1(2H)-one

参考文献

1. David Remillard, et al. ACS Chem Biol. 2021 Nov 19;16(11):2185-2192.