EA-89-YM35 | BRD9 inhibitor | Probechem Biochemicals

Chemical Structure : EA-89-YM35

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EA-89-YM35 (BRD9 inhibitor EA-89)

货号: PC-49152Not For Human Use, Lab Use Only.

BRD9 inhibitor EA-89 is a potent and selective inhibitor that binds to BRD9 in a novel way.

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生物&药学活性

BRD9 inhibitor EA-89 is a potent and selective inhibitor that binds to BRD9 in a novel way.
EA-89 binds to the acetyl lysine pocket similar to other known bromodomain chemotypes, forming a direct hydrogen bond with the conserved Asn100.
EA-89 produces a strongly selective profile across a subset of leukemia lines with no impact on the viability of THP-1, HEL, or HCT116.

物理化学性质&存储条件

分子量	594.789
分子式	C31H38N4O4S2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-(1,1-dioxidotetrahydro-2H-thiopyran-4-yl)-7-(3-methyl-1-(piperidin-4-ylmethyl)-1H-indol-5-yl)-4-oxo-5-propyl-4,5-dihydrothieno[3,2-c]pyridine-2-carboxamide

参考文献

1. Ellen Weisberg, et al. Blood Cancer J. 2022 Jul 19;12(7):110.

EA-89-YM35 (BRD9 inhibitor EA-89)

生物&药学活性

物理化学性质&存储条件

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EA-89-YM35 (BRD9 inhibitor EA-89)

生物&药学活性

物理化学性质&存储条件

参考文献

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