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首页-小分子抑制剂&激动剂-Epigenetics-Bromodomain-BI-9564
BI-9564

Chemical Structure : BI-9564

CAS No.: 1883429-22-8

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BI-9564 (BI 9564, BI9564)

货号: PC-42110Not For Human Use, Lab Use Only.

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.

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5 mg ￥580 In stock
10 mg ￥880 In stock
25 mg ￥1480 In stock
50 mg ￥2580 In stock
100 mg Get quote
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BI-9564 (BI9564) is a potent, selective, cell-permeable and noncytotoxic BRD9 bromodomain inhibitor with IC50 of 75 nM, Kd of <20 nM.
BI-9564 displays 45-fold selectiveity over BRD7, and >5,000-fold over BRD4-BD1, BRD4-BD2, and BRD2-BD1.
BI-9564 blocks EOL-1 cell proliferation with EC50 of 0.8 uM, and displays antitumor activity in an AML xenograft model.

物理化学性质&存储条件

分子量 353.4149
分子式 C20H23N3O3
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

DMSO: 7.2 mg/mL (Need warming)
Chemical Name/SMILES

4-(4-((dimethylamino)methyl)-2,5-dimethoxyphenyl)-2-methyl-2,7-naphthyridin-1(2H)-one

参考文献

1. Martin LJ, et al. J Med Chem. 2016 May 26;59(10):4462-75.

2. Krämer KF, et al. Int J Mol Sci. 2017 Jul 16;18(7). pii: E1537.

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