BAY-850 | ATAD2 inhibitor | Probechem Biochemicals

Chemical Structure : BAY-850

CAS No.: 2099142-76-2

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BAY-850 (BAY 850, BAY850)

货号: PC-60022Not For Human Use, Lab Use Only.

BAY-850 (BAY 850, BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.

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5 mg	￥2580	In stock
10 mg	￥3980	In stock
25 mg	￥5980	In stock
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100 mg		Get quote

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生物&药学活性

BAY-850 (BAY850) is a potent, isoform selective, cellularly active ATAD2 bromodomain inhibitor with binding IC50 of 166 nM in TR-FRET assay.
BAY-850 shows no inhibitory activity in a panel of 354 kinases and only modest effects on a few GPCRs.
BAY-850 displaces a tetra-acetylated H4 peptide with an IC50 of 22 nM, and the tetra-acetylated peptides with IC50 of 115 nM.
BAY-850 pecifically induces ATAD2 bromodomain dimerization and prevents interactions with acetylated histones in vitro, as well as with chromatin in cells.

物理化学性质&存储条件

分子量	654.252
分子式	C38H44ClN5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5-((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

参考文献

1. Fernández-Montalván AE, et al. ACS Chem Biol. 2017 Nov 17;12(11):2730-2736.

BAY-850 (BAY 850, BAY850)

生物&药学活性

物理化学性质&存储条件

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BAY-850 (BAY 850, BAY850)

生物&药学活性

物理化学性质&存储条件

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