CPI-637 |CAS:1884712-47-3 Probechem Biochemicals

Chemical Structure : CPI-637

CAS No.: 1884712-47-3

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CPI-637 (CPI637;CPI 637)

货号: PC-42168Not For Human Use, Lab Use Only.

A potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM.

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10 mg	￥1180	In stock
25 mg	￥1880	In stock
50 mg	￥2880	In stock
100 mg		Get quote

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生物&药学活性

CPI-637 is a potent and selective, cell-active CBP/EP300 bromodomain inhibitor with CBP BRET EC50 of 0.03 uM.
CPI-637 displays >700-fold selectivity over the BET bromodomains (BRD4 IC50=11.0 uM).
CPI-637 is also highly selective against other bromodomains.
CPI-637 inhibits the expression of MYC with an EC50 of 0.60 uM in a cellular assay.

物理化学性质&存储条件

分子量	386.4497
分子式	C22H22N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO
Chemical Name/SMILES	2H-1,5-Benzodiazepin-2-one, 1,3,4,5-tetrahydro-4-methyl-6-[1-methyl-3-(1-methyl-1H-pyrazol-4-yl)-1H-indazol-5-yl]-, (4R)-

参考文献

1. Taylor AM, et al. ACS Med Chem Lett. 2016 Mar 15;7(5):531-6.

CPI-637 (CPI637;CPI 637)

生物&药学活性

物理化学性质&存储条件

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CPI-637 (CPI637;CPI 637)

生物&药学活性

物理化学性质&存储条件

参考文献

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