JQ-1 carboxylic acid |CAS:202592-23-2 Probechem Biochemicals

Chemical Structure : JQ-1 carboxylic acid

CAS No.: 202592-23-2

加入收藏

JQ-1 carboxylic acid ((+)-JQ-1 carboxylic acid)

货号: PC-45994Not For Human Use, Lab Use Only.

JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones.

规格	价格	库存
25 mg	￥1280	In stock
50 mg	￥1880	In stock
100 mg	￥2880	In stock
200 mg		Get quote
1 g		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

JQ-1 carboxylic acid is an inhibitor of bromodomain and extra terminal domain (BET) family proteins with Kd of 128, 59.5, 49.0, and 190 nM for JQ1 binding to bromodomains of BRD2, BRD3, BRD4, and BRDT, respectively, blocking their interaction with acetylated histones.
JQ-1 carboxylic acid is a chemical probe to investigate the role of BET bromodomains in the transcriptional regulation of oncogenesis.

物理化学性质&存储条件

分子量	400.8819
分子式	C19H17ClN4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO
Chemical Name/SMILES	6H-Thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepine-6-acetic acid, 4-(4-chlorophenyl)-2,3,9-trimethyl-, (6S)-

参考文献

1. Filippakopoulos P, et al. Nature. 2010 Dec 23;468(7327):1067-73.

2. Mertz JA, et al. Proc Natl Acad Sci U S A. 2011 Oct 4;108(40):16669-74.

3. Dawson MA, et al. Nature. 2011 Oct 2;478(7370):529-33.

JQ-1 carboxylic acid ((+)-JQ-1 carboxylic acid)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

JQ-1 carboxylic acid ((+)-JQ-1 carboxylic acid)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.