BRM014 | BRG1/BRM inhibitor | Probechem Biochemicals

Chemical Structure : BRM014

CAS No.: 2270879-17-7

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BRM014 (BRM-014, Dual BRM and BRG1 inhibitor 14)

货号: PC-35746Not For Human Use, Lab Use Only.

BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both.

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2 mg	￥3880	In stock
5 mg	￥5880	In stock
10 mg	￥9580	In stock
25 mg		Get quote
100 mg		Get quote

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生物&药学活性

BRM014 (BRM-014) is a potent, orally active inhibitor of Brahma Homolog (BRM)/SMARCA2 and Brahma-related gene 1 (BRG1) with IC50 of <5 nM for both.
BRM014 modulates SWI/SNF chromatin-remodeling activity via inhibition of the ATPase activity.
BRM014 downregulates BRM-dependent gene expression and shows antiproliferative activity in a BRG1-mutant-lung-tumor xenograft model.

物理化学性质&存储条件

分子量	318.274
分子式	C11H9F3N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1-(3-(difluoromethyl)isothiazol-5-yl)-3-(2-fluoro-5-(hydroxymethyl)pyridin-4-yl)urea

参考文献

1. Papillon JPN, et al. J Med Chem. 2018 Oct 31. doi: 10.1021/acs.jmedchem.8b01318.
2. Rago F, et al. Mol Cancer Res. 2022 Mar 1;20(3):361-372.

BRM014 (BRM-014, Dual BRM and BRG1 inhibitor 14)

生物&药学活性

物理化学性质&存储条件

参考文献

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BRM014 (BRM-014, Dual BRM and BRG1 inhibitor 14)

生物&药学活性

物理化学性质&存储条件

参考文献

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