ZL0420 |CAS: 2229039-45-4 Probechem Biochemicals

Chemical Structure : ZL0420

CAS No.: 2229039-45-4

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ZL0420 (ZL-0420;ZL 0420)

货号: PC-35096Not For Human Use, Lab Use Only.

ZL0420 (ZL-0420) is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.

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10 mg	￥1380	In stock
25 mg	￥2180	In stock
50 mg	￥3880	In stock
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生物&药学活性

ZL0420 (ZL-0420) is a potent, highly selective BRD4 inhibitor with IC50 of 27 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
ZL0420 (ZL-0420) displays selectivity over BRD2, BRD3, and BRDT (BRD2-BD1 and BRD2-BD2, IC50=803 and 1736 nM).
ZL0420 (ZL-0420) disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.54 and 0.51 uM).
ZL0420 (ZL-0420) blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.

物理化学性质&存储条件

分子量	296.33
分子式	C16H16N4O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-6-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-3,4-dihydroquinolin-2(1H)-one

参考文献

1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151.

2. Liu Z, et al. Eur J Med Chem 2018 May 10;151:450-461.

ZL0420 (ZL-0420;ZL 0420)

生物&药学活性

物理化学性质&存储条件

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ZL0420 (ZL-0420;ZL 0420)

生物&药学活性

物理化学性质&存储条件

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