ZL0454 |CAS: 2229042-77-5 Probechem Biochemicals

Chemical Structure : ZL0454

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ZL0454 (ZL-0454;ZL 0454)

货号: PC-35097Not For Human Use, Lab Use Only.

ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.

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生物&药学活性

ZL0454 is a potent, highly selective small-molecule BRD4 inhibitor with IC50 of 49 and 32 nM for BRD4-BD1 and BRD4-BD2, respectively.
ZL0454 displays selectivity over BRD2, BRD3, and BRDT( BRD2-BD1 and BRD2-BD2, IC50=772 and 1836 nM).
ZL0454 disrupts the BRD4 complex with Pol II and histones, inhibits poly(I:C)-induced expression of innate immune genes IL6 and CIG5 in human small airway epithelial cells (hSAECs) (IC50=0.62 and 0.57 uM).
ZL0454 blocks Poly(I:C)-induced inflammation and neutrophilia in vivo.

物理化学性质&存储条件

分子量	374.459
分子式	C18H22N4O3S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(E)-4-((2-amino-4-hydroxy-5-methylphenyl)diazenyl)-N-cyclopentylbenzenesulfonamide

参考文献

1. Tian B, et al. Cell Rep. 2018 Apr 24;23(4):1138-1151.

ZL0454 (ZL-0454;ZL 0454)

生物&药学活性

物理化学性质&存储条件

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ZL0454 (ZL-0454;ZL 0454)

生物&药学活性

物理化学性质&存储条件

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