SGC-iMLLT

Chemical Structure : SGC-iMLLT

CAS No.: 2255338-25-9

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货号: PC-35710Not For Human Use, Lab Use Only.

SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1).

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

SGC-iMLLT is the first small molecule chemical probe for the YEATS domain (YD) of MLLT1 (ENL/YEATS1) and MLLT3 (AF9/YEATS3) with Kd of 129 and 77 nM respectively, IC50 of 0.26 uM (MLLT1).
SGC-iMLLT is a potent and selective inhibitor of MLLT1/3-histone interaction.
SGC-iMLLT dsiplays excellent selectivity over other human YD proteins (YEATS2/4) and bromodomains.

物理化学性质&存储条件

分子量	388.475
分子式	C22H24N6O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-1-methyl-N-(2-((2-methylpyrrolidin-1-yl)methyl)-1H-benzo[d]imidazol-5-yl)-1H-indazole-5-carboxamide

参考文献

1. Moustakim M, et al. Angew Chem Int Ed Engl. 2018 Oct 5. doi: 10.1002/anie.201810617.

SGC-iMLLT

生物&药学活性

物理化学性质&存储条件

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SGC-iMLLT

生物&药学活性

物理化学性质&存储条件

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