GSK4027 |CAS:2079896-25-4 Probechem Biochemicals

Chemical Structure : GSK4027

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GSK4027 (GSK 4027;GSK-4027)

货号: PC-35554Not For Human Use, Lab Use Only.

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe inhibitor of PCAF/GCN5 bromodomain with pKi of 8.9 for both.

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生物&药学活性

GSK4027 (GSK 4027, GSK-4027) is a potent, selective, cell-penetrant chemical probe inhibitor of PCAF/GCN5 bromodomain with pKi of 8.9 for both.
GSK4027 displays exceptional selectivity over the BET bromodomain family (>18000-fold selectivity over the BET family, >70-fold selectivity over the wider bromodomain families) and proof of cellular target engagement.
GSK4027 is a useful chemical tool in elucidating the biological phenotype of PCAF/GCN5 bromodomain inhibition.

物理化学性质&存储条件

分子量	377.286
分子式	C17H21BrN4O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-Bromo-2-methyl-5-(((3R,5R)-1-methyl-5-phenylpiperidin-3-yl)amino)pyridazin-3(2H)-one

参考文献

1. Humphreys PG, et al. J Med Chem. 2017 Jan 26;60(2):695-709.

GSK4027 (GSK 4027;GSK-4027)

生物&药学活性

物理化学性质&存储条件

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GSK4027 (GSK 4027;GSK-4027)

生物&药学活性

物理化学性质&存储条件

参考文献

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