GNE-371 |CAS:1926986-36-8 Probechem Biochemicals

Chemical Structure : GNE-371

CAS No.: 1926986-36-8

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GNE-371 (GNE371;GNE 371)

货号: PC-35709Not For Human Use, Lab Use Only.

GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members.

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5 mg	￥3880	In stock
10 mg	￥5880	In stock
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100 mg		Get quote

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生物&药学活性

GNE-371 (GNE371) is a highly potent and selective chemical probe for the second bromodomain of TAF1 (TAF1(2)) with IC50/Kd of 10/1 nM, without significant activity against other bromodomain-family members.
GNE-371 (GNE371) is also active in a cellular-TAF1(2) target-engagement assay (IC50=38 nM).
GNE-371 exhibits antiproliferative synergy with the BET inhibitor JQ1, suggesting engagement of endogenous TAF1 by GNE-371.

物理化学性质&存储条件

分子量	431.496
分子式	C24H25N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-But-3-enyl-4-[1-methyl-6-(morpholine-4-carbonyl)-benzimidazol-4-yl]-1H-pyrrolo[2,3-c]pyridin-7-one

参考文献

1. Wang S, et al. J Med Chem. 2018 Oct 25;61(20):9301-9315.

GNE-371 (GNE371;GNE 371)

生物&药学活性

物理化学性质&存储条件

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GNE-371 (GNE371;GNE 371)

生物&药学活性

物理化学性质&存储条件

参考文献

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