| Cat. No. |
Product Name |
Information |
| PC-62439 |
AMG-548
p38α inhibitor
|
AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ. |
| PC-61210 |
SC-806
p38 MAPK inhibitor
|
SC-806 is a potent, orally active p38 MAPK inhibitor with IC50 of 50 nM, significantly decreases incidence of arthritis in mouse collagen-induced arthritis. |
| PC-61001 |
AS1940477
p38α/β inhibitor
|
AS1940477 is a potent, selective, orally active p38α/p38β inhibitor with IC50 of 11.2/36.5 nM respectively, with no effect on p38γ and δ isoforms (IC50>1 uM). |
| PC-60627 |
RWJ 67657
p38 MAPK inhibitor
|
RWJ 67657 (JNJ 3026582) is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively. |
| PC-60434 |
MW-150
p38α MAPK inhibitor
|
MW-150 (MW01-18-150 SRM, MW150) is a novel potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM. |
| PC-60432 |
MW-150 hydrochloride
p38α inhibitor
|
MW-150 hydrochloride is a potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM. |
| PC-45059 |
Acumapimod
p38 MAPK inhibitor
|
An orally active, potent p38 MAPK inhibitor that potently inhibits ex vivo LPS‐induced TNFα secretion with an IC50 of 44 ng/mL (115 nM). |
| PC-42491 |
SB203580
p38 MAPK inhibitor
|
SB203580 (Adezmapimod, RWJ 64809) is a specific p38 MAPK inhibitor with IC50 of 0.6 uM. |
| PC-42564 |
Losmapimod
p38 MAPK inhibitor
|
Losmapimod (GSK-AHAB, GW856553X, SB856553) is a selective, potent, orally active p38 MAPK inhibitor with pKi of 8.1 and 7.6 for p38α and p38β, respectively. |
| PC-45452 |
SB-242235
p38 MAPK inhibitor
|
SB-242235 is a selective p38 MAPK inhibitor, inhibits IL-1 beta induction of p38 MAPK in primary human chondrocytes with IC50 of 1 uM. |
| PC-42563 |
VX-702
p38 MAPK inhibitor
|
VX-702 is a potent, selective, second generation p38 MAPK inhibitor with IC50 of 4-20 nM for p38α. |
| PC-42565 |
Pamapimod
p38α MAPK inhibitor
|
Pamapimod (Ro4402257; R1503) is a potent, selective, orally bioavailable p38α MAPK inhibitor with Kd of 0.2 nM. |
