p38 MAPK (inhibitors, antagonists, agonists)-ProbeChem.com

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Cat. No.	Product Name	Information
PC-42512	SB202190 p38 MAPK inhibitor	SB202190 (SB 202190, SB-202190) is a potent inhibitor p38α and p38β with IC50 of 50 nM and 100 nM respectively.
PC-42526	Neflamapimod p38α MAPK inhibitor	Neflamapimod (VX-745) is a potent and selective p38α kinase inhibitor with IC50 of 9 nM.
PC-42520	Doramapimod p38 MAPK inhibitor	Doramapimod (BIRB-796) is a highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
PC-28692	SB-747651A dihydrochloride MSK1 inhibitor	SB-747651A dihydrochloride (SB747651A) is a potent, specific and ATP-competitive inhibitor of MSK1 (mitogen- and stress-activated kinase 1) with IC50 of 11 nM.
PC-27852	Koumine IGF2BP3 inhibitor, MAPK inhibitor	Koumine is an alkaloid derived from Gelsemium elegans within antitumor, immunosuppressive, anti-inflammatory, and analgesic properties, inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss via suppression of the MAPK signaling, also binds IGF2BP3 and promotes its proteasome-dependent degradation.
PC-24997	CHR-3464 p38α inhibitor	CHR-3464 is a potent, selective p38α MAPK inhibitor with IC50 of 1.86 nM, inhibits the production of TNF-α from THP-1 cells with IC50 of 1.5 nM.
PC-24996	MPL-5821 p38α inhibitor	MPL-5821 is a potent and myeloid selective p38α MAPK inhibitor, could be hydrolysied by hCE-1 to active form MPL-5822.
PC-24763	GLPG0259 MAPKAPK5 inhibitor	GLPG0259 is a potent, specific, ATP-competitive and orally bioavailable mitogen-activated protein kinase-activated protein kinase 5 (MAPKAPK5, PRAK, MK5) inhibitor.
PC-23866	ULTR-p38i 2015 p38α inhibitor	ULTR-p38i 2015 is a potent, selective type 1.5 p38α inhibitor with IC50 of 4.8 nM, specifically inhibits p38α and p38β.
PC-23072	GEn-1124 p38α/MK2 modulator	GEn-1124 is a first-in-class small molecule modulator of p38α/MK2 signaling targeted to a pocket near the ED substrate binding domain of p38α, destabilizes the MK2: p38 complex.
PC-21600	BMS-582949 p38 MAPK inhibitor	BMS-582949 is a potent, selective and orally active p38α MAP kinase inhibitor with IC50 of 13 nM, exhibits significant inhibition of TNFα release in hPBMC with IC50 of 50 nM.
PC-21599	Dilmapimod p38 MAPK inhibitor	SB-681323 is a potent and selective p38 MAPK inhibitor, potentially suppresses inflammation in chronic obstructive pulmonary disease.

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