Doramapimod (BIRB796) | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : Doramapimod

CAS No.: 285983-48-4

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Doramapimod (BIRB 796, BIRB-796, BIRB796)

货号: PC-42520Not For Human Use, Lab Use Only.

Doramapimod (BIRB-796) is a highly potent p38 MAPK inhibitor with Kd of 0.1 nM.

规格	价格	库存
5 mg	￥480	In stock
10 mg	￥680	In stock
25 mg	￥980	In stock
50 mg	￥1480	In stock
100 mg		Get quote

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生物&药学活性

Doramapimod (BIRB-796) is a highly potent p38 MAPK inhibitor with Kd of 0.1 nM.
Doramapimod (BIRB-796) displays no activity on ERK1, IKK2b, ZAP-70, EGFR, PKA, PKC, etc
Doramapimod (BIRB-796) shows inhibition of TNFα inTHP.1 with IC50 of 18 nM.
Doramapimod (BIRB-796) is orally active.

物理化学性质&存储条件

分子量	527.6572
分子式	C31H37N5O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-[3-(1,1-dimethylethyl)-1-(4-methylphenyl)-1H-pyrazol-5-yl]-N'-[4-[2-(4-morpholinyl)ethoxy]-1-naphthalenyl]-

参考文献

1. Pargellis C, et al. Nat Struct Biol. 2002 Apr;9(4):268-72.

2. Regan J, et al. J Med Chem. 2002 Jul 4;45(14):2994-3008.

3. Gruenbaum LM, et al. Biochem Pharmacol. 2009 Feb 1;77(3):422-32.

Doramapimod (BIRB 796, BIRB-796, BIRB796)

生物&药学活性

物理化学性质&存储条件

参考文献

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Doramapimod (BIRB 796, BIRB-796, BIRB796)

生物&药学活性

物理化学性质&存储条件

参考文献

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