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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-GEn-1124
GEn-1124

Chemical Structure : GEn-1124

CAS No.: 2769682-89-3

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GEn-1124 (GEn1124, SF-7-044 dihydrochloride dihydrate)

货号: PC-23072Not For Human Use, Lab Use Only.

GEn-1124 is a first-in-class small molecule modulator of p38α/MK2 signaling targeted to a pocket near the ED substrate binding domain of p38α, destabilizes the MK2: p38 complex.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

GEn-1124 is a first-in-class small molecule modulator of p38α/MK2 signaling targeted to a pocket near the ED substrate binding domain of p38α, destabilizes the MK2: p38 complex.

物理化学性质&存储条件

分子量 534.49
分子式 C23H33Cl2N3O5S
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

5-(dimethylamino)-N-(4-(morpholinomethyl)phenyl)naphthalene-1-sulfonamide dihydrochloride dihydrate

参考文献

1. Tulapurkar ME, et al. J Pharmacol Exp Ther. 2024 Sep 16:JPET-AR-2024-002281.

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