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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-BMS-582949
BMS-582949

Chemical Structure : BMS-582949

CAS No.: 623152-17-0

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BMS-582949 (BMS 582949)

货号: PC-21600Not For Human Use, Lab Use Only.

BMS-582949 is a potent, selective and orally active p38α MAP kinase inhibitor with IC50 of 13 nM, exhibits significant inhibition of TNFα release in hPBMC with IC50 of 50 nM.

规格 价格 库存 数量
5 mg ￥1580 In stock
10 mg ￥2480 In stock
25 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

BMS-582949 is a potent, selective and orally active p38α MAP kinase inhibitor with IC50 of 13 nM, exhibits significant inhibition of TNFα release in hPBMC with IC50 of 50 nM.

物理化学性质&存储条件

分子量 406.49
分子式 C22H26N6O2
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4-((5-(Cyclopropylcarbamoyl)-2-methylphenyl)amino)-5-methyl-N-propylpyrrolo[2,1-f][1,2,4]triazine-6-carboxamide

参考文献

1. Liu C, et al. J Med Chem. 2010 Sep 23;53(18):6629-39.

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