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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-Koumine
Koumine

Chemical Structure : Koumine

CAS No.: 1358-76-5

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Koumine

货号: PC-27852Not For Human Use, Lab Use Only.

Koumine is an alkaloid derived from Gelsemium elegans within antitumor, immunosuppressive, anti-inflammatory, and analgesic properties, inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss via suppression of the MAPK signaling, also binds IGF2BP3 and promotes its proteasome-dependent degradation.

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25 mg ￥980 In stock
50 mg ￥1480 In stock
100 mg ￥2480 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

Koumine is an alkaloid derived from Gelsemium elegans within antitumor, immunosuppressive, anti-inflammatory, and analgesic properties, inhibits osteoclastogenesis and prevents ovariectomy-induced bone loss via suppression of the MAPK signaling, also binds IGF2BP3 and promotes its proteasome-dependent degradation.
Koumine dose-dependently inhibits osteoclast formation and bone resorption without cytotoxicity in ovariectomized (OVX) mouse model.
Koumine suppresses osteoclastogenesis and protects against bone loss, an effect associated with inhibition of MAPK signaling.
Koumine suppresses gastric cancer (GC) cancer growth in vivo, markedly reduces collagen (COL21A1, COL3A1, COL13A1, and COL14A1) expression in GC cells and significantly increases T-cell infiltration into the tumors.
Koumine inhibits RANKL-induced ubiquitination and NF-κB activation to prevent ovariectomy and aging-induced bone loss.

物理化学性质&存储条件

分子量 306.40
分子式 C20H22N2O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

(3S,4S,4aR,6R,11bS,11cS)-2-Methyl-11c-vinyl-1,2,3,4,4a,5,6,11c-octahydro-6,4-(epoxymethano)-3,11b-methanopyrido[4,3-c]carbazole

参考文献

1. Lin H, et al. Eur J Pharmacol. 2025 Oct 5;1004:177954.

2. Hongqiang Q, et al. Cancer Sci. 2026 Aug 25:10.1111/cas.70514.

3. Zhang X, et al. Sci Rep. 2026 Jun 13. doi: 10.1038/s41598-026-57325-4.

4. You J, et al. J Cell Biochem. 2024 Jan;125(1):100-114.

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