ULTR-p38i 2015 | p38α inhibitor | Probechem Biochemicals

Chemical Structure : ULTR-p38i 2015

加入收藏

ULTR-p38i 2015 (ULTR-p38i)

货号: PC-23866Not For Human Use, Lab Use Only.

ULTR-p38i 2015 is a potent, selective type 1.5 p38α inhibitor with IC50 of 4.8 nM, specifically inhibits p38α and p38β.

规格	价格	库存	数量
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote

获取报价单

* 请选择数量再加入购物车

or Bulk Inquiry

大包装，大折扣！

E-mail: sales@probechem.com

Tech Support: tech@probechem.com

生物&药学活性

ULTR-p38i 2015 is a potent, selective type 1.5 p38α inhibitor with IC50 of 4.8 nM, specifically inhibits p38α and p38β.
ULTR-p38i 2015 shows no actiivity against a panel of 340 kinases, apart from a moderate influence on JNK2.
ULTR-p38i 2015 increases cell death induction and reduces MK2 T334 phosphorylation in organoids overexpression of oncogenic Myc (KrasG12D;MycOE;Trp53−/−).
ULTR-p38i 2015 manipulates the mitotic entry and induce mitotic catastrophe in CRC.
ULTR-p38i 2015 induces apoptosis and cellular senescence in CRC, blocks metastatic CRC development.
ULTR-p38i 2015 strongly reduces cell viability in a panel of human CRC cell lines (HCT-15, HCT 116, COLO 205, LS 174T, RKO and HT-29).
ULTR-p38i 2015 shows strong activity in different CRC models, with no adverse effects on mice.

物理化学性质&存储条件

分子量	457.51
分子式	C27H24FN3O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	8-((3-(cyclopropanecarboxamido)-4-fluorophenyl)amino)-N-methyl-5-oxo-10,11-dihydro-5H-dibenzo[a,d][7]annulene-3-carboxamide

参考文献

1. Rudalska R, et al. Nat Cancer. 2025 Jan 16. doi: 10.1038/s43018-024-00899-7.

ULTR-p38i 2015 (ULTR-p38i)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

ULTR-p38i 2015 (ULTR-p38i)

生物&药学活性

物理化学性质&存储条件

参考文献

Bulk Inquiry

* Indicates a Required FieldYour information is safe with us.

询单

Get Quotation Now

* Indicates a Required FieldYour information is safe with us.