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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-PF-03715455
PF-03715455

Chemical Structure : PF-03715455

CAS No.: 1056164-52-3

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PF-03715455 (PF03715455)

货号: PC-63103Not For Human Use, Lab Use Only.

PF-03715455 is a highly potent and selective inhibitor for p38α MAPK with IC50 of 1.6 nM.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    PF-03715455 is a highly potent and selective inhibitor for p38α MAPK with IC50 of 1.6 nM.
    PF-03715455 shows efficacy and safety profiles as an inhaled agent for the treatment of COPD.

    物理化学性质&存储条件

    分子量 700.273
    分子式 C35H34ClN7O3S2
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-(3-(tert-butyl)-1-(3-chloro-4-hydroxyphenyl)-1H-pyrazol-5-yl)-3-(2-((3-(2-((2-hydroxyethyl)thio)phenyl)-[1,2,4]triazolo[4,3-a]pyridin-6-yl)thio)benzyl)urea

    参考文献

    1. Millan DS, et al. J Med Chem. 2011 Nov 24;54(22):7797-814.

    2. Singh D, et al. Eur J Clin Pharmacol. 2015 Oct;71(10):1175-84.

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