MW181 dihydrochloride |CAS:1628503-08-1 Probechem Biochemicals

Chemical Structure : MW181 dihydrochloride

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MW181 dihydrochloride (MW01-10-181SRM)

货号: PC-62783Not For Human Use, Lab Use Only.

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

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1 g		Get quote

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生物&药学活性

MW181 (MW01-10-181SRM) is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ; suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production, suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice, significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.

物理化学性质&存储条件

分子量
分子式
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine dihydrochloride

参考文献

1. Maphis N, et al. Alzheimers Res Ther. 2016 Dec 15;8(1):54.

2. Bachstetter AD, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60.

3. Watterson DM, et al. PLoS One. 2013 Jun 26;8(6):e66226.

MW181 dihydrochloride (MW01-10-181SRM)

生物&药学活性

物理化学性质&存储条件

参考文献

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MW181 dihydrochloride (MW01-10-181SRM)

生物&药学活性

物理化学性质&存储条件

参考文献

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