NJK14047 | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : NJK14047

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NJK14047 (NJK 14047, NJK-14047)

货号: PC-62614Not For Human Use, Lab Use Only.

NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.

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25 mg		Get quote
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100 mg		Get quote

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生物&药学活性

NJK14047 is a novel potent, selective p38 MAPK inhibitor with IC50 of 27 nM against p38α, suppresses RSV and influenza A virus replication by inhibiting virus-induced p38 MAPK activation.
NJK14047 inhibits RSV- and influenza A-mediated p38 MAPK activation in epithelial cells, decreases viral replication and viral mRNA synthesis.
NJK14047 also displays significant anti-HBV activity, efficiently suppresses the secretion of HBV antigens and HBV particles from HBV genome-transfected cells.

物理化学性质&存储条件

分子量	445.515
分子式	C27H27NO5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N-cyclopropyl-4'-(4-(2,3-dihydroxypropoxy)benzoyl)-6-methyl-[1,1'-biphenyl]-3-carboxamide

参考文献

1. Kim SY, et al. Antimicrob Agents Chemother. 2017 Jul 25;61(8). pii: e00214-17.

2. Choi MS, et al. Biochem Biophys Res Commun. 2016 Aug 26;477(3):311-6.

3. Heo J, et al. Bioorg Med Chem Lett. 2015 Sep 1;25(17):3694-8.

NJK14047 (NJK 14047, NJK-14047)

生物&药学活性

物理化学性质&存储条件

参考文献

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NJK14047 (NJK 14047, NJK-14047)

生物&药学活性

物理化学性质&存储条件

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