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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-AMG-548
AMG-548

Chemical Structure : AMG-548

CAS No.: 864249-60-5

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AMG-548 (AMG548)

货号: PC-62439Not For Human Use, Lab Use Only.

AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ.

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10 mg ￥3980 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

AMG-548 is a potent and selective inhibitor of p38α with Ki of 0.5 nM, dispalys weak inhibition for p38β (Ki=3.6 nM), and >5,000-fold selectivity over p38γ and p38δ.
AMG-548 shows >1,000-fold selectivity over other 36 kinases, and is efficacious in acute and chronic models of arthritis.

物理化学性质&存储条件

分子量 461.569
分子式 C29H27N5O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20 °C 12 个月; 4°C 6 个月
配置液
-80 °C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

2-[[(2S)-2-Amino-3-phenylpropyl]amino]-3-methyl-5-(2-naphthalenyl)-6-(4-pyridinyl)-4(3H)-pyrimidinone

参考文献

1. Verkaar F, et al. Chem Biol. 2011 Apr 22;18(4):485-94.

2. Lee MR, et al. Curr Med Chem. 2005;12(25):2979-94.

3. Dominguez C, et al. Curr Opin Drug Discov Devel. 2005 Jul;8(4):421-30.

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