RWJ 67657 | p38 MAPK inhibitor | Probechem Biochemicals

Chemical Structure : RWJ 67657

CAS No.: 215303-72-3

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RWJ 67657 (JNJ 3026582, RWJ67657, RWJ-67657)

货号: PC-60627Not For Human Use, Lab Use Only.

RWJ 67657 (JNJ 3026582) is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥2180	In stock
50 mg	￥3580	In stock
100 mg		Get quote

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生物&药学活性

RWJ 67657 (JNJ 3026582) is a potent, selective, orally active p38 MAPK inhibitor that inhibits the production of TNF-α and IL-1β by LPS-stimulated human PBMCs with IC50 of 3 and 11 nM, respectively.
RWJ 67657 inhibits p38α from purified LPS-activated human monocytes with IC50 of 30 nM, less potent for p38β.
RWJ 67657 also inhibits Src (IC50=5 uM), p65 Lck and no activity against other MAPKs and serine-threonine kinases.
RWJ 67657 inhibits TNF-alpha production in LPS-injected mice.

物理化学性质&存储条件

分子量	425.5
分子式	C27H24FN3O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[4-(4-fluorophenyl)-1-(3-phenylpropyl)-5-(4-pyridinyl)-1H-imidazol -2-yl]-3-butyn-1-ol

参考文献

1. Wadsworth SA, et al. J Pharmacol Exp Ther. 1999 Nov;291(2):680-7.

2. Schafer PH, et al. J Immunol. 1999 Jun 15;162(12):7110-9.

3. Fijen JW, et al. Clin Exp Immunol. 2001 Apr;124(1):16-20.

4. Faas MM, et al. Clin Exp Immunol. 2002 Feb;127(2):337-43.

RWJ 67657 (JNJ 3026582, RWJ67657, RWJ-67657)

生物&药学活性

物理化学性质&存储条件

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RWJ 67657 (JNJ 3026582, RWJ67657, RWJ-67657)

生物&药学活性

物理化学性质&存储条件

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