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首页-小分子抑制剂&激动剂-Ras-Raf-MAPK-ERK Pathway-p38 MAPK-AW-814141
AW-814141

Chemical Structure : AW-814141

CAS No.: 905285-51-0

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AW-814141 (AW814141)

货号: PC-63000Not For Human Use, Lab Use Only.

AW-814141 (AW814141) is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    AW-814141 (AW814141) is a potent, selective and orally active inhibitor of p38 MAP kinase with IC50 of 100 nM/158 nM for p38α/p38β.
    AW-814141 inhibits the release of TNF-alpha by lipopolysaccharide (LPS) treated human peripheral blood mononuclear cells with IC50 of 212 nM.
    AW-814141 inhibits paw swelling in CIA models.

    物理化学性质&存储条件

    分子量 375.476
    分子式 C22H25N5O
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20 °C 12 个月; 4°C 6 个月
    配置液
    -80 °C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    2-(hexahydrocyclopenta(c)pyrrol-2-ylamino)-8-methyl-6-o-tolyl-8H-pyrido(2,3-d)pyrimidine-7-one

    参考文献

    1. Chopra P, et al. Int Immunopharmacol. 2010 Apr;10(4):467-73.

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