MW181 hydrochloride | p38α inhibitor | Probechem Biochemicals

Chemical Structure : MW181 hydrochloride

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MW181 hydrochloride (MW01-10-181SRM)

货号: PC-62782Not For Human Use, Lab Use Only.

MW181 hydrochloride is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.

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生物&药学活性

MW181 hydrochloride is an isoform-selective, brain-permeable, and orally bioavailable small molecule inhibitor of p38α MAPK with Ki of 184 nM, no affitnity for CK1δ.
MW181 suppresses p38α MAPK activation, reduces tau phosphorylation, and decreases proinflammatory cytokine production, suppresses LPS-induced increases in mouse brain IL-1β, TNFα, IL-6, IL-10, and CXCL1 in mice.
MW181 significantly increases synaptophysin protein expression and prevents cognitive impairment in the aged hTau mice.

物理化学性质&存储条件

分子量	362.86
分子式	C21H19ClN4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N,N-dimethyl-6-(naphthalen-1-yl)-5-(pyridin-4-yl)pyridazin-3-amine hydrochloride

参考文献

1. Maphis N, et al. Alzheimers Res Ther. 2016 Dec 15;8(1):54.

2. Bachstetter AD, et al. J Neuroimmune Pharmacol. 2014 Sep;9(4):454-60.

3. Watterson DM, et al. PLoS One. 2013 Jun 26;8(6):e66226.

MW181 hydrochloride (MW01-10-181SRM)

生物&药学活性

物理化学性质&存储条件

参考文献

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MW181 hydrochloride (MW01-10-181SRM)

生物&药学活性

物理化学性质&存储条件

参考文献

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