MW-150 hydrochloride | p38α inhibitor | Probechem Biochemicals

Chemical Structure : MW-150 hydrochloride

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MW-150 hydrochloride (MW01-18-150SRM, MW 150, MW150)

货号: PC-60432Not For Human Use, Lab Use Only.

MW-150 hydrochloride is a potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM.

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生物&药学活性

MW-150 hydrochloride is a potent, selective, CNS penetrant and orally active inhibitor of p38α MAPK with Ki of 101 nM.
MW-150 effectively suppresses hippocampal-dependent associative and spatial memory deficits in synaptic dysfunction mouse models.
MW-150 also can selectively modulate neuroinflammatory responses associated with pathology progression.

物理化学性质&存储条件

分子量	417.94
分子式	C24H24ClN5
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	6-(4-methylpiperazin-1-yl)-3-(naphthalen-2-yl)-4-(pyridin-4-yl)pyridazine hydrochloride

参考文献

1. Roy SM, et al. ACS Chem Neurosci. 2015 Apr 15;6(4):666-80.

2. Zhou Z, et al. J Neuroinflammation. 2017 Apr 5;14(1):75.

MW-150 hydrochloride (MW01-18-150SRM, MW 150, MW150)

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物理化学性质&存储条件

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MW-150 hydrochloride (MW01-18-150SRM, MW 150, MW150)

生物&药学活性

物理化学性质&存储条件

参考文献

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