| Cat. No. |
Product Name |
Information |
| PC-27858 |
WRX606
mTORC1 inhibitor
|
WRX606 is an orally active, allosteric inhibitor of mTOR complex 1 (mTORC1) with Kd of 1.3 uM, forms a ternary complex with FK506-binding protein-12 (FKBP12) and FKBP–rapamycin-binding (FRB) domain of mTOR. |
| PC-27760 |
mTOR inhibitor CD25
mTOR inhibitor
|
mTOR inhibitor CD25 is a non-covalent mTOR inhibitor, suppresses NLRP3-GSDMD inflammasome-mediated pyroptosis and inflammation. |
| PC-27759 |
MHY1485
mTOR activator
|
MHY1485 is a specific small molecule mTOR activator, targets the ATP domain of mTOR, inhibits autophagy with an mTOR activating effect. |
| PC-27225 |
WYE-28
mTOR inhibitor
|
WYE-28 is a potent, selective and ATP-competitive inhibitor of mTOR with IC50 of 0.08 nM, inhibits PI3Kα with IC50 of 6 nM. |
| PC-26698 |
AcTor
TSC2 inhibitor/mTORC1 activator
|
AcTor is a specific small molecule TSC2 inhibitor and mTOR stimulator, activates mTORC1 in the presence of ixazomib and potentiates ixazomibactivity across multiple AML cell lines. |
| PC-26250 |
NUCC-201760
mTORC2 SIN1 inhibitor
|
NUCC-201760 is a specific small molecules inhibitor of mTORC2 complex component Stress-activated protein kinase-interacting protein 1 (SIN1) with IC50 of <1.5 uM in p-AKT S473 flow cytometry assay, selectively targets mTORC2 but not mTORC1. |
| PC-21000 |
AZD2014
mTOR inhibitor
|
Vistusertib (AZD2014) is a potent and selective dual mTORC1 and mTORC2 inhibitor, inhibits both mTORC1 and mTORC2 in vitro (pS6 (S235/236), IC50=0.2 μM, pAKT (S473) IC50=0.08 μM). |
| PC-49619 |
XL388
mTOR inhibitor
|
XL388 (XL-388) is a potent, selective and orally bioavailable mTOR inhibitor with IC50 of 9.9 nM. |
| PC-49618 |
RMC-6272
mTORC1 inhibitor
|
RMC-6272 (RMC6272) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.44 nM for p4EBP1 inhibition, 27-fold selectivity over mTORC2. |
| PC-49617 |
RMC-5552
mTORC1 inhibitor
|
RMC-5552 (RMC5552) is a potent, selective bi-steric inhibitor of mTORC1 with cellular IC50 of 0.48 nM for p4EBP1 inhibition, 40-fold selectivity over mTORC2. |
| PC-49337 |
NV-5297
mTORC1 activator
|
NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo. |
| PC-38333 |
BC-LI-0186
LeuRS inhibitor
|
BC-LI-0186 is a potent, specific inhibitor of Leucyl-tRNA synthetase (LRS), inhibits the leucine-dependent mTORC1 pathway. |
