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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-mTOR-MHY1485
MHY1485

Chemical Structure : MHY1485

CAS No.: 326914-06-1

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MHY1485 (MHY-1485)

货号: PC-27759Not For Human Use, Lab Use Only.

MHY1485 is a specific small molecule mTOR activator, targets the ATP domain of mTOR, inhibits autophagy with an mTOR activating effect.

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50 mg ￥1280 In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

MHY1485 is a specific small molecule mTOR activator, targets the ATP domain of mTOR, inhibits autophagy with an mTOR activating effect.
MHY1485 inhibits starvation-induced colocalization between autophagosomes and lysosomes, leading to accumulation of LC3II protein and enlarged autophagosomes in rat hepatocytes and also induced the activity of mTOR.
MHY1485 activates mTOR and protects osteoblasts from dexamethasone.
MHY1485 ameliorates UV-induced skin cell damages via activating mTOR-Nrf2 signaling.

物理化学性质&存储条件

分子量 387.40
分子式 C17H21N7O4
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

4,6-dimorpholino-N-(4-nitrophenyl)-1,3,5-triazin-2-amine

参考文献

1. Choi YJ, et al. PLoS One. 2012;7(8):e43418.

2. Hu XK, et al. Mol Med Rep. 2016 Oct;14(4):3662-8.

3. Yang B, et al. Oncotarget. 2017 Feb 21;8(8):12775-12783.

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