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首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-mTOR-NUCC-201760
NUCC-201760

Chemical Structure : NUCC-201760

CAS No.:

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NUCC-201760 (NUCC201760)

货号: PC-26250Not For Human Use, Lab Use Only.

NUCC-201760 is a specific small molecules inhibitor of mTORC2 complex component Stress-activated protein kinase-interacting protein 1 (SIN1) with IC50 of <1.5 uM in p-AKT S473 flow cytometry assay, selectively targets mTORC2 but not mTORC1.

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纯度 & COA & 质检文件 纯度: >98% (HPLC)

生物&药学活性

NUCC-201760 is a specific small molecules inhibitor of mTORC2 complex component Stress-activated protein kinase-interacting protein 1 (SIN1) with IC50 of <1.5 uM in p-AKT S473 flow cytometry assay, selectively targets mTORC2 but not mTORC1.
NUCC-201760 uniquely inhibits RAS activity and downstream MAPK signaling, disrupts the ability of RAS to switch from the GDP to GTP form which requires SIN1.
NUCC-201760 enhances responses to different FDA approved pharmacological agents in U937 cells.
NUCC-201760 alters post-translational modification, protein-protein interactions, and blocks mTORC2- and rapamycin sensitive (RS) mTORC1-mediated signaling.
NUCC-201760 potently inhibits the growth of colon cancer, melanoma, and leukemia cell lines.

物理化学性质&存储条件

分子量 523.98
分子式 C29H25ClF3N3O
外观性状 Solid
CAS No.
储存条件
固体粉末
-20°C 12 个月; 4°C 6 个月
配置液
-80°C 6 个月; -20°C 6 个月
Shipping
Solubility

10 mM in DMSO
Chemical Name/SMILES

N-(4'-chloro-3'-(trifluoromethyl)-[1,1'-biphenyl]-3-yl)-1-(quinolin-8-ylmethyl)piperidine-4-carboxamide

参考文献

1. Beauchamp EM, et al. Mol Cancer Ther. 2025 Dec 22. doi: 10.1158/1535-7163.MCT-25-0298.

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