XL388 | mTOR inhibitor | Probechem Biochemicals

Chemical Structure : XL388

CAS No.: 1251156-08-7

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XL388 (XL-388)

货号: PC-49619Not For Human Use, Lab Use Only.

XL388 (XL-388) is a potent, selective and orally bioavailable mTOR inhibitor with IC50 of 9.9 nM.

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5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2580	In stock
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100 mg		Get quote

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生物&药学活性

XL388 (XL-388) is a potent, selective and orally bioavailable mTOR inhibitor with IC50 of 9.9 nM.
XL388 displays no significant activity against PI3K members with IC50 of >3 uM.
XL388 inhibited cellular phosphorylation of mTOR complex 1 (p-p70S6K, pS6, and p-4E-BP1) and mTOR complex 2 (pAKT (S473)) substrates.
XL388 displayed good pharmacokinetics and oral exposure in multiple species with moderate bioavailability.
Oral administration of compound 28 to athymic nude mice implanted with human tumor xenografts afforded significant and dose-dependent antitumor activity.

物理化学性质&存储条件

分子量	455.50
分子式	C23H22FN3O4S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	[7-(6-Amino-3-pyridinyl)-2,3-dihydro-1,4-benzoxazepin-4(5H)-yl][3-fluoro-2-methyl-4-(methylsulfonyl)phenyl]methanone

参考文献

1. Takeuchi CS, et al. J Med Chem. 2013 Mar 28;56(6):2218-34.

2. Zhu YR, et al. Oncotarget. 2016 Aug 2;7(31):49527-49538.

XL388 (XL-388)

生物&药学活性

物理化学性质&存储条件

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XL388 (XL-388)

生物&药学活性

物理化学性质&存储条件

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