| Cat. No. |
Product Name |
Information |
| PC-42608 |
PP242
mTOR inhibitor
|
Torkinib (PP242) is a potent, specific active-site inhibitor of mTOR with IC50 of 30 and 58 nM for mTORC1 and mTORC2, respectively. |
| PC-42576 |
AZD-8055
mTOR inhibitor
|
AZD-8055 is a potent, selective, ATP-competitive and orally bioavailable mTOR inhibitor with IC50 of 0.8 nM. |
| PC-45098 |
Onatasertib
mTOR inhibitor
|
Onatasertib (CC-223, ATG-008) is a potent, selective, and orally bioavailable inhibitor of mTOR kinase with IC50 of 16 nM. |
| PC-45902 |
Deforolimus
mTOR inhibitor
|
Deforolimus (AP-23573, MK-8669, Ridaforolimus) potent, selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line. |
| PC-42463 |
Everolimus
mTOR inhibitor
|
Everolimus (RAD001) is a potent, highly specific, orally active mTOR inhibitor with IC50 of 5-6 nM for binding to FKBP-12 or FKBP-12 complexed to mTOR. |
| PC-42092 |
CZ-415
mTOR inhibitor
|
CZ-415 (CZ415) potent, highly selective, ATP-competitive and orally bioavailable mTOR inhibitor with pKd of 8.2. |
| PC-45461 |
mTOR-IN-1
mTOR inhibitor
|
mTOR-IN-1 is a potent and selective mTOR inhibitor with Ki of 1.5 nM. |
| PC-42577 |
OSI-027
mTOR inhibitor
|
OSI-027 (ASP7486) is a potent and selective inhibitor of mTORC1 and mTORC2 with IC50 of 22 nM and 65 nM, respectively. |
| PC-42038 |
PQR-620
mTOR inhibitor
|
PQR-620 (PQR620) is a potent and selective, brain penetrant inhibitor of mTORC1/2, displays >1000-fold selectivity towards mTOR over PI3Kα in enzymatic binding assays. |
| PC-45102 |
CC-115 hydrochloride
DNA-PK/mTOR inhibitor
|
CC-115 hydrochloride is a potent, dual inhibitor of mTOR and DNA-PK with IC50 of 21 nM and 13 nM, respectively. |
| PC-42464 |
Rapamycin
mTOR inhibitor
|
Rapamycin (Sirolimus) is a macrolide compound that has potent immunosuppressive and antiproliferative properties by inhibiting mTOR (IC50=0.1 nM), induces autophagy. |
| PC-28764 |
Tomatidine hydrochloride
mTORC1 activator, ATF4 inhibitor
|
Tomatidine hydrochloride is a steroidal alkaloid derived from green tomatoes, stimulates mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and cell growth, inhibits ATF4 activity in aged skeletal muscle. |
