Deforolimus |CAS:572924-54-0 Probechem Biochemicals

Chemical Structure : Deforolimus

CAS No.: 572924-54-0

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Deforolimus (AP-23573;MK-8669;Ridaforolimus)

货号: PC-45902Not For Human Use, Lab Use Only.

Deforolimus (AP-23573, MK-8669, Ridaforolimus) potent, selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line.

规格	价格	库存
10 mg	￥780	In stock
25 mg	￥1280	In stock
50 mg	￥1980	In stock
100 mg	￥3280	In stock
250 mg		Get quote
1 g		Get quote

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生物&药学活性

Deforolimus (AP-23573, MK-8669, Ridaforolimus) potent, selective mTOR inhibitor with IC50 of 0.2 nM in HT-1080 cell line.
Deforolimus displays significant antiproliferative activity a broad panel of cell lines with EC50 of 0.2-2.3 nM.
Deforolimus potently and selectively inhibits VEGF production in a dose-dependent manner.
Deforolimus exerts significant antitumor effects in mice bearing PC-3 (prostate), HCT-116 (colon), MCF7 (breast), PANC-1 (pancreas) or A549 (lung) xenografts.

物理化学性质&存储条件

分子量	990.2061
分子式	C53H84NO14P
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: ≥ 44 mg/mL
Chemical Name/SMILES	Rapamycin, 42-(dimethylphosphinate) (9CI)

参考文献

1. Rivera VM, et al. Mol Cancer Ther. 2011 Jun;10(6):1059-71.

2. Legrier ME, et al. Cancer Res. 2007 Dec 1;67(23):11300-8.

3. Becker MA, et al. BMC Cancer. 2016 Oct 20;16(1):814.

Deforolimus (AP-23573;MK-8669;Ridaforolimus)

生物&药学活性

物理化学性质&存储条件

参考文献

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Deforolimus (AP-23573;MK-8669;Ridaforolimus)

生物&药学活性

物理化学性质&存储条件

参考文献

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