AZD-8055 |CAS:1009298-09-2 Probechem Biochemicals

Chemical Structure : AZD-8055

CAS No.: 1009298-09-2

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AZD-8055 (AZD8055;AZD 8055)

货号: PC-42576Not For Human Use, Lab Use Only.

AZD-8055 is a potent, selective, ATP-competitive and orally bioavailable mTOR inhibitor with IC50 of 0.8 nM.

规格	价格	库存
25 mg	￥1580	In stock
100 mg	￥3580	In stock
200 mg		Get quote
1 g		Get quote

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生物&药学活性

AZD-8055 is a potent, selective, ATP-competitive and orally bioavailable mTOR inhibitor with IC50 of 0.8 nM.
AZD-8055 shows excellent selectivity (1,000-fold) against all class I PI3K isoforms and other PI3K-like kinases.
AZD-8055 inhibits the phosphorylation of mTORC1 substrates p70S6K and 4E-BP1, and phosphorylation of the mTORC2 substrate AKT and downstream proteins, also fully inhibits rapamycin-resistant T37/46 phosphorylation sites on 4E-BP1.
AZD-8055 potently inhibits proliferation and induces autophagy in H838 and A549 cells, exhibits tumor growth inhibition in vivo.

物理化学性质&存储条件

分子量	465.5447
分子式	C25H31N5O4
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Benzenemethanol, 5-[2,4-bis[(3S)-3-methyl-4-morpholinyl]pyrido[2,3-d]pyrimidin-7-yl]-2-methoxy-

参考文献

1. Chresta CM, et al. Cancer Res. 2010 Jan 1;70(1):288-98.

2. Sini P, et al. Autophagy. 2010 May;6(4):553-4.

3. Jiang Q, et al. Cancer Res. 2011 Jun 15;71(12):4074-84.

4. Willems L, et al. Leukemia. 2012 Jun;26(6):1195-202.

AZD-8055 (AZD8055;AZD 8055)

生物&药学活性

物理化学性质&存储条件

参考文献

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AZD-8055 (AZD8055;AZD 8055)

生物&药学活性

物理化学性质&存储条件

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