| Cat. No. |
Product Name |
Information |
| PC-38176 |
NV-5138
mTORC1 activator
|
Mefluleucine (NV-5138, NV5138) is the first selective, orally bioavailable brain mTORC1 activator, binds to Sestrin2 (Kd=1.5 uM) and activates mTORC1 both in vitro and in vivo. |
| PC-36112 |
MTI-31
mTOR inhibitor
|
MTI-31 (LXI-15029, mTOR inhibitor-31) is a novel potent, selective mTORC1/mTORC2 inhibitor with Kd of 0.2 nM (mTOR), displays >5,000-fold selectivity over PIK3CA, PIK3CB and PIK3G. |
| PC-35518 |
ICSN3250 hydrochloride
mTOR inhibitor
|
ICSN3250 (ICSN-3250) hydrochloride is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors. |
| PC-35517 |
ICSN3250
mTOR inhibitor
|
ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors. |
| PC-35070 |
Seco Rapamycin
|
Seco-rapamycin is the first in vivo open-ring metabolite of rapamycin that does not affect mTOR.. |
| PC-63577 |
GPI-1046
FKBP12 ligand
|
GPI-1046 is a non-immunosuppressive ligand of the immunophilin FKBP12. |
| PC-43497 |
Sapanisertib
mTORC1/2 inhibitor
|
Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms. |
| PC-43313 |
Torin2
mTOR inhibitor
|
Torin2 is a potent, selective, orally available inhibitor of mTOR, inhibits mTORC1-dependent T389 phosphorylation on S6K with IC50 of 0.25 nM, exhibits 800-fold selectivity over PI3K, and >100-fold over 440 other protein kinases. |
| PC-43314 |
Torin1
mTOR inhibitor
|
Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM). |
| PC-43029 |
Zotarolimus
FKBP ligand
|
Zotarolimus (ABT-578, A 179578) is a semi-synthetic analogue of rapamycin, inhibits FKBP-12 binding with IC50 of 2.8 nM and shows less potent systemic immunosuppression than rapamycin. |
| PC-42848 |
WYE-354
mTOR inhibitor
|
WYE-354 is a potent, selective and ATP-competitive inhibitor of mTOR with IC50 of 5 nM (recombinant mTOR ), displays >100-fold selectivity over PI3K isofoms. |
| PC-62364 |
CID3528206
Yeast TORC1 inhibitor
|
CID3528206 is a potent, small molecule yeast TORC1 inhibitor that inhibits TORC1 activity both in vitro and in vivo with IC50 of 150 nM and 3.9 uM, respectively. |
