NV-5297 | mTORC1 activator | Probechem Biochemicals

Chemical Structure : NV-5297

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NV-5297 (NV5297)

货号: PC-49337Not For Human Use, Lab Use Only.

NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo.

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生物&药学活性

NV-5297 (NV5297) is a novel small molecule mTORC1 pathway activator, modulates the Sestrin2-Gator2 interaction and activates the mTORC1 pathway in vitro and in vivo.
NV-5297 is a leucine analog activating the mTORC1 pathway in the brain and peripheral tissues.
NV-5297 disrupted the Sestrin2/GATOR2 interaction in a dose-dependent manner in HEK293T cells stably expressing flag-WDR24, a component of GATOR2, NV-5297 treatment in leucine-starved cells also increased p70S6K1 in a dose-dependent manner.
NV-5297 activated mTORC1, increased striatal volume, improved motor learning and heart contractility in the N171-82Q huntington's disease (HD) mouse model, ameliorated motor behavior and striatal deficits in HD mice.

物理化学性质&存储条件

分子量	199.173
分子式	C7H12F3NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(S)-2-amino-5,5,5-trifluoro-4,4-dimethylpentanoic acid

参考文献

1. Sophie St-Cyr, et al. PLoS One. 2022 Aug 29;17(8):e0273710.

NV-5297 (NV5297)

生物&药学活性

物理化学性质&存储条件

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NV-5297 (NV5297)

生物&药学活性

物理化学性质&存储条件

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