ICSN3250 | mTOR inhibitor | Probechem Biochemicals

Chemical Structure : ICSN3250

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ICSN3250 (ICSN-3250)

货号: PC-35517Not For Human Use, Lab Use Only.

ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.

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生物&药学活性

ICSN3250 (ICSN-3250) is a halitulin-analogue that acts as a new-class, specific mTOR inhibitor through a mechanism distinct from previous mTOR inhibitors.
ICSN3250 is not a kinase inhibitor of mTOR, competes with and displaces phosphatidic acid from the FRB domain in mTOR, thus preventing mTOR activation and leading to cytotoxicity.
ICSN3250 displays no inhibitory capacity towards PI3Kα, β, γ, or δ.
ICSN3250 inhibits mTORC1 by following an unprecedented mechanism that involved its competition with PA at the FRB domain of mTOR to overcome the TSC negative regulation of mTORC1.
ICSN3250 specifically targets cancer cells both in vitro and ex vivo.

物理化学性质&存储条件

分子量	596.681
分子式	C31H40N4O8
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	5,5'-(1-(3-(azacyclotridecan-1-yl)propyl)-1H-pyrrole-3,4-diyl)bis(3-nitrobenzene-1,2-diol)

参考文献

1. Nguyen TL, et al. Cancer Res. 2018 Jul 27. pii: canres.0232.2018.

ICSN3250 (ICSN-3250)

生物&药学活性

物理化学性质&存储条件

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ICSN3250 (ICSN-3250)

生物&药学活性

物理化学性质&存储条件

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