Sapanisertib |CAS:1224844-38-5 Probechem Biochemicals

Chemical Structure : Sapanisertib

CAS No.: 1224844-38-5

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Sapanisertib (INK-128, MLN0128, TAK-228, CB-228)

货号: PC-43497Not For Human Use, Lab Use Only.

Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms.

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25 mg	￥1780	In stock
100 mg	￥3880	In stock
500 mg	￥8480	In stock
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生物&药学活性

Sapanisertib (INK-128, MLN0128, TAK-228) is a potent, ATP-competitive, orally active dual mTORC1/2 inhibitor with Ki of 1.4 nM in cell-free assays, >200-fold selectivity over calss I PI3K isoforms.
Sapanisertib (INK-128, MLN0128) inhibits both the phosphorylation of S6 and 4EBP1, the downstream substrates of TORC1, and selectively inhibits AKT phosphorylation at Ser473, the downstream substrate of TORC2.
Sapanisertib (INK-128, MLN0128) also shows potent inhibition effects on cell lines resistant to rapamycin and pan-PI3K inhibitors.
Sapanisertib (INK-128, MLN0128) shows tumor growth inhibition efficacy in multiplexenograft models.

物理化学性质&存储条件

分子量	309.33
分子式	C15H15N7O
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 3-(2-amino-5-benzoxazolyl)-1-(1-methylethyl)-

参考文献

1. Hsieh AC, et al. Nature. 2012 Feb 22;485(7396):55-61.

2. Gökmen-Polar Y, et al. Breast Cancer Res Treat.

3. Maiso P, et al. Blood. 2011 Dec 22;118(26):6860-70.

4. Janes MR, et al. Leukemia. 2013 Mar;27(3):586-94.

Sapanisertib (INK-128, MLN0128, TAK-228, CB-228)

生物&药学活性

物理化学性质&存储条件

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Sapanisertib (INK-128, MLN0128, TAK-228, CB-228)

生物&药学活性

物理化学性质&存储条件

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