Torin1 | mTOR inhibitor | Probechem Biochemicals

Chemical Structure : Torin1

CAS No.: 1222998-36-8

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Torin1 (Torin 1;Torin-1)

货号: PC-43314Not For Human Use, Lab Use Only.

Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM).

规格	价格	库存
5 mg	￥780	In stock
10 mg	￥1180	In stock
25 mg	￥1980	In stock
50 mg	￥3280	In stock
100 mg		Get quote

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生物&药学活性

Torin1 is a highly potent, selective inhibitor of mTORC1 and mTORC2 with IC50 of 2 and 10 nM in cell-free assays, exhibits 1,000-fold selectivity PI3K (EC50=1,800 nM).
Torin1 exhibits 100-fold binding selectivity relative to 450 other protein kinases.
Torin1 causes cell cycle arrest through a rapamycin-resistant mechanism that is also independent of mTORC2, disrupts mTORC1-dependent phenotypes more completely than rapamycin.
Torin1 prevents the anti-inflammatory potency of GC both in human monocytes and myeloid dendritic cells.

物理化学性质&存储条件

分子量	607.6243
分子式	C35H28F3N5O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	DMSO: 6.6 mg/mL (Need ultrasonic or warming)
Chemical Name/SMILES	Benzo[h]-1,6-naphthyridin-2(1H)-one, 1-[4-[4-(1-oxopropyl)-1-piperazinyl]-3-(trifluoromethyl)phenyl]-9-(3-quinolinyl)-

参考文献

1. Thoreen CC, et al. J Biol Chem. 2009 Mar 20;284(12):8023-32.

2. Liu Q, et al. J Med Chem. 2010 Oct 14;53(19):7146-55.

3. Weichhart T, et al. Blood. 2011 Apr 21;117(16):4273-83.

4. Thoreen CC, et al. Autophagy. 2009 Jul;5(5):725-6.

Torin1 (Torin 1;Torin-1)

生物&药学活性

物理化学性质&存储条件

参考文献

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Torin1 (Torin 1;Torin-1)

生物&药学活性

物理化学性质&存储条件

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