| Cat. No. |
Product Name |
Information |
| PC-28763 |
Tomatidine
mTORC1 activator, ATF4 inhibitor
|
Tomatidine is a steroidal alkaloid derived from green tomatoes, stimulates mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and cell growth, inhibits ATF4 activity in aged skeletal muscle. |
| PC-27954 |
Aloe-emodin
mTORC2 inhibitor, HER-2 inhibitor
|
Aloe-emodin (Aloe emodin, Rhabarberone) is a natural hydroxyanthraquinone with antitumor activities, binds and inhibits mTORC2, inhibits both proliferation and anchorage-independent growth of PC3 cells, also inhibits HER-2 expression through the downregulation of Y-box binding protein-1 (YB-1), inhibits cancer metastasis and cancer stem cells. |
| PC-27312 |
DEPTOR-IN-3
DEPTOR inhibitor
|
DEPTOR-IN-3 (Compound 4g) is a small molecule inhibitor of DEPTOR-mTOR interaction, induces p70 phosphorylation, shows anti-myeloma cytotoxic properties. |
| PC-27311 |
DEPTOR-IN-2
DEPTOR inhibitor
|
DEPTOR-IN-2 (Compound 3g, Drug 3g) is a small molecule inhibitor of DEPTOR-mTOR interaction, prevents binding of recombinant DEPTOR to mTOR with IC50 of 1 uM, induces DEPTOR degradation, shows anti-myeloma cytotoxic properties. |
| PC-27310 |
NSC126405
DEPTOR inhibitor
|
NSC126405 is a small-molecule DEPTOR inhibitor that prevent DEPTOR binding to mTOR, acutely activates mTORC1 and selectively induces MM cell apoptosis and cell cycle arrest, binds to recombinant DEPTOR but not mTOR. |
| PC-27309 |
DEPTOR-IN-1
DEPTOR inhibitor
|
DEPTOR-IN-1 (Compound C3) is a small molecule putative DEPTOR inhibitor with MST KD of 9.3 uM, exhibits antimultiple myeloma activity with IC50 of 1.09 uM for RPMI 8226 cells. |
| PC-24226 |
TMBIM6 inhibitor BIA
TMBIM6 inhibitor
|
TMBIM6 inhibitor BIA is a specific inhibitor of TMBIM6 (BAX inhibitor-1, BI-1), prevents TMBIM6 binding to mTORC2, decreases mTORC2 activity, also suppresses ER release of Ca2+ from TMBIM6, has broad anticancer activities. |
| PC-62011 |
CIDD 0067106
|
CIDD 0067106 is a novel natural product-based diaryloxazole that potent and selective antiproliferative activities against androgen receptor-positive breast cancer cells (MDA-MB-453 cell GI50=0.8 uM). |
