Tomatidine

Chemical Structure : Tomatidine

CAS No.: 77-59-8

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货号: PC-28763Not For Human Use, Lab Use Only.

规格	价格	库存
10 mg	￥580	In stock
25 mg	￥980	In stock
50 mg	￥1580	In stock
100 mg		Get quote

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生物&药学活性

Tomatidine is a steroidal alkaloid derived from green tomatoes, stimulates mTORC1 signaling and anabolism, leading to accumulation of protein and mitochondria, and cell growth, inhibits ATF4 activity in aged skeletal muscle.
Tomatidine increased skeletal muscle mTORC1 signaling, reduced skeletal muscle atrophy, enhanced recovery from skeletal muscle atrophy, stimulated skeletal muscle hypertrophy, and increased strength and exercise capacity in mice.
Tomatidine specifically potentiated the inhibitory effect of aminoglycosides but not of other classes of drugs, against Staphylococcus aureus.
Tomatidine suppresses inflammation in primary articular chondrocytes and attenuates cartilage degradation in osteoarthritic rats.

物理化学性质&存储条件

分子量	415.66
分子式	C27H45NO2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(2aS,4S,5'S,6aS,6bS,8aS,8bR,9S,10S,11aS,12aS,12bR)-5',6a,8a,9-Tetramethyloctadecahydrospiro[naphtho[2',1':4,5]indeno[2,1-b]furan-10,2'-piperidin]-4-ol

参考文献

1. Dyle MC, et al. J Biol Chem. 2014 May 23;289(21):14913-24.

2. Mitchell G, et al. J Antimicrob Chemother. 2012 Mar;67(3):559-68.

3. Ebert SM, et al. J Biol Chem. 2015 Oct 16;290(42):25497-511.

4. Chu X, et al. Aging (Albany NY). 2020 Jul 5;12(13):12799-12811.

Tomatidine

生物&药学活性

物理化学性质&存储条件

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Tomatidine

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