mTOR-IN-1 |CAS:1207358-59-5 Probechem Biochemicals

首页-小分子抑制剂&激动剂-PI3K/Akt/mTOR Pathway-mTOR-mTOR-IN-1

Chemical Structure : mTOR-IN-1

CAS No.: 1207358-59-5

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mTOR-IN-1

货号: PC-45461Not For Human Use, Lab Use Only.

mTOR-IN-1 is a potent and selective mTOR inhibitor with Ki of 1.5 nM.

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10 mg	￥2280	In stock
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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

生物&药学活性

mTOR-IN-1 is a potent and selective mTOR inhibitor with Ki of 1.5 nM.
mTOR-IN-1 shows >500-fold selectivity over closely related PI3 kinases.
mTOR-IN-1 exhibits suitable mouse PK and demenstrates active in an NCI-PC3prostate cancer model; orally bioavailable.

物理化学性质&存储条件

分子量	474.5581
分子式	C25H30N8O2
外观性状	Solid
CAS No.
储存条件	固体粉末 -20 °C 12 个月; 4°C 6 个月	配置液 -80 °C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	Urea, N-ethyl-N'-[4-[5,6,7,8-tetrahydro-4-[(3S)-3-methyl-4-morpholinyl]-7-(2-pyrimidinyl)pyrido[3,4-d]pyrimidin-2-yl]phenyl]-

参考文献

1. Koehler MF, et al. J Med Chem. 2012 Dec 27;55(24):10958-71.

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mTOR-IN-1

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mTOR-IN-1

生物&药学活性

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