mTOR inhibitor CD25

Chemical Structure : mTOR inhibitor CD25

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货号: PC-27760Not For Human Use, Lab Use Only.

mTOR inhibitor CD25 is a non-covalent mTOR inhibitor, suppresses NLRP3-GSDMD inflammasome-mediated pyroptosis and inflammation.

规格	价格	库存	数量
25 mg		Get quote
50 mg		Get quote
100 mg		Get quote

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生物&药学活性

mTOR inhibitor CD25 is a non-covalent mTOR inhibitor, suppresses NLRP3-GSDMD inflammasome-mediated pyroptosis and inflammation.
CD25 dose-dependently suppresses the secretion of IL-1β, a key indicator of NLRP3 inflammasome activation, in both THP-1 and J774A.1 cells following LPS/nigericin stimulation.
CD25 attenuates IL-1β secretion triggered by diverse other canonical NLRP3 activators, including ATP, MSU, and Alum.
CD25 inhibits the priming process of NLRP3 inflammasome activation.
CD25 inhibits ASC oligomerization and speck formation in both THP-1-derived macrophages and J774A.1 cells.
CD25 preserves mitochondrial function in THP-1 cells, alleviates mitochondrial dysfunction to inhibit pyroptosis.
CD25 blocks pyroptosis by targeting the mTOR signaling pathway.
CD25 alleviates LPS-induced sepsis and APAP-induced liver injury in mice.

物理化学性质&存储条件

分子量	360.48
分子式	C18H24N4O2S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	N4-(cyclohexylmethyl)-N2-(4-(methylsulfonyl)phenyl)pyrimidine-2,4-diamine

参考文献

1. Jiang X, et al. Biochem Pharmacol. 2026 Jan;243(Pt 1):117459.