| Cat. No. |
Product Name |
Information |
| PC-20047 |
GDC-1971
SHP2 inhibitor
|
Migoprotafib (GDC-1971, RLY-1971) is a potent, selective, allosteric and orally bioavailable inhibitor of the non-receptor protein tyrosine phosphatase SHP2 (PTPN11), potently inhibits both wild-type SHP2 (IC50 <1 nM) and E76K activating mutant (IC50 < 250nM) in biochemical assays. |
| PC-49364 |
SPAA-52
LMW-PTP inhibitor
|
SPAA-52 is a highly potent, selective inhibitor of the low-molecular-weight protein tyrosine phosphatase (LMW-PTP) with Ki of 1.2 nM, >8000-fold selectivity over other PTPs. |
| PC-49299 |
DS-1211
TNAP inhibitor
|
DS-1211 (DS1211) is a potent, selecitve inhibitor of tissue-nonspecific alkaline phosphatase (TNAP) with IC50 of 3.4 nM. |
| PC-49084 |
NSC49L
PP2A agonist
|
NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation. |
| PC-49039 |
PP2Cδ (WIP1) inhibitor C23
PP2Cδ inhibitor
|
PP2Cδ inhibitor C23 is a potent PP2Cδ (WIP1, PPM1D) inhibitor, not only directly inhibits PP2Cδ activity but also suppresses high glucose (HG)-induced PP2Cδ expression. |
| PC-49037 |
CCT007093
PP2Cδ/PPM1D/Wip1 inhibitor
|
CCT007093 is a small-molecule inhibitor of PP2Cδ (WIP1, PPM1D) with IC50 of 8.4 uM, selectively reduces viability of human tumour cell lines. |
| PC-38898 |
K306
SHIP1 agonist
|
K306 is a specific, small molecule agonist of SH2-containing 5' inositol phosphatase 1 (SHIP1) with EC50 of 119 nM, 10-fold higher selectivity over SHIP2. |
| PC-38538 |
AQX-016A
SHIP1 agonist
|
AQX-016A is a potent, selective small molecule agonist of SHIP1 phosphatase activity, upregulates SHIP1 activity in the PI3K signaling pathway in cells, without acitivty for SHIP2 phosphatase activity. |
| PC-38476 |
GSK2830371
Wip1 phosphatase inhibitor
|
GSK2830371 (GSK 2830371) is a potent, selective orally active, allosteric inhibitor of Wip1 phosphatase (PPM1D) with IC50 of 6 nM, inhibits endogenous substrates phospho-p38 MAPK (T180) with IC50 of 13 nM. |
| PC-38405 |
Lockdown Ester Prodrug
PPM1F inhibitor
|
Lockdown Ester Prodrug (Lockdown Pro) is the ester-modified Lockdown with increased membrane permeability and prodrug-like properties, a selective small-molecule inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion. |
| PC-38404 |
Lockdown
PPM1F inhibitor
|
Lockdown is a selective, reversible and non-competitive inhibitor of the integrin phosphatase PPM1F, blocks cancer cell invasion. |
| PC-73348 |
NHB1109
PTPRD inhibitor
|
NHB1109 (Pentilludin) is a potent, selective, orally active PTPRD phosphatase inhibitor with IC50 of 0.6 uM, displays selectivity over PTPRS, PTPRF, PTPRJ or PTPN1/PTP1B phosphatases. |
