PHPS1 | SHP2 inhibitor | Probechem Biochemicals

Chemical Structure : PHPS1

CAS No.: 314291-83-3

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PHPS1 (Phenylhydrazonopyrazolone sulfonate 1)

货号: PC-20340Not For Human Use, Lab Use Only.

PHPS1 is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM.

规格	价格	库存
5 mg	￥980	In stock
10 mg	￥1480	In stock
25 mg	￥2380	In stock
50 mg	￥3980	In stock
100 mg		Get quote

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生物&药学活性

PHPS1 is a potent, specific and cell-permeable inhibitor of protein tyrosine phosphatase Shp2 with Ki value of 0.73 uM.
PHPS1 displays 8- and 15-fold selectivity against most closely related PTPs, PTP1B, and Shp1.
PHPS1 (5 μM) inhibits HGF/SF-induced scattering and branching morphogenesis of MDCK epithelial cells.
PHPS1 inhibits Shp2-dependent signaling pathways, inhibits Erk1/2 but not Akt and Stat3 phosphorylation in a dose-dependent manner in MDCK cells.
PHPS1 effectively inhibits anchorage-independent growth of human tumor cells, which correlates strongly with their tumorigenicity and invasiveness.

物理化学性质&存储条件

分子量	465.44
分子式	C21H15N5O6S
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	4-[2-[1,5-dihydro-3-(4-nitrophenyl)-5-oxo-1-phenyl-4H-pyrazol-4-ylidene]hydrazinyl]-benzenesulfonic acid

参考文献

1. Klaus Hellmuth, et al. Proc Natl Acad Sci U S A. 2008 May 20;105(20):7275-80.

PHPS1 (Phenylhydrazonopyrazolone sulfonate 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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PHPS1 (Phenylhydrazonopyrazolone sulfonate 1)

生物&药学活性

物理化学性质&存储条件

参考文献

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