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首页-小分子抑制剂&激动剂-Metabolic Enzyme/Protease-Protein Phosphatase/PTP-NSC49L
NSC49L

Chemical Structure : NSC49L

CAS No.: 64401-41-8

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NSC49L (NSC30049)

货号: PC-49084Not For Human Use, Lab Use Only.

NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation.

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纯度 & COA & 质检文件 纯度: >98% (HPLC) Select Batch:

    生物&药学活性

    NSC49L (NSC30049) is a small molecule agonist (activator) of protein phosphatase 2A (PP2A), specifically stimulates PP2A-Cα activity with Kact of 14 nM, downregulates the AKT1/mTOR/4EBP1-axis, and inhibits p21 translation.
    NSC49L (NSC30049) interacts with the catalytic subunit C of the PP2A and stimulates its activity.
    NSC49L (NSC30049) treatment increases the colocalization of eIF4E with unphosphorylated 4EBP1 and inhibits p21 protein synthesis in FOLFOX-HT29 cells.
    Caspase 3 inhibitor ZDEVD reverses the cytotoxic effect of NSC49L and TRAIL in FOLFOX-HT29 cells.
    NSC49L (NSC30049) induces TRAIL/caspase-3-dependent apoptosis of FOLFOX-resistant CRC cells.
    NSC49L (NSC30049) also inhibited Chk1 pathway in 5-FU-resistant CRC bulk and stem cell populations.
    NSC49L (NSC30049) showed very potent activity in a HDTX model of CRC stem cell tumors either alone or in combination with 5-FU.

    物理化学性质&存储条件

    分子量 265.182
    分子式 C10H18Cl2N4
    外观性状 Solid
    CAS No.
    储存条件
    固体粉末
    -20°C 12 个月; 4°C 6 个月
    配置液
    -80°C 6 个月; -20°C 6 个月
    Shipping
    Solubility

    10 mM in DMSO
    Chemical Name/SMILES

    1-((E)-4-Chlorobut-2-en-1-yl)-1,3,5,7-tetraazaadamantan-1-ium Chloride

    参考文献

    1. Narayan S, et al. Oncotarget. 2017 Aug 1;8(34):57246-57264.

    2. Narayan S, et al. iScience. 2022 Jun 3;25(7):104518.

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