| Cat. No. |
Product Name |
Information |
| PC-72461 |
MLS000544460
EYA2 inhibitor
|
MLS000544460 (EYA2i) is a specific, allosteric inhibitor of Eya2 phosphatase with IC50 of 4.1 uM, KD of 2.0 uM, does not bind Eya3 ED, Eya1 and Eya4 ED. |
| PC-72452 |
NCGC00249987
EYA2 inhibitor
|
NCGC00249987 (Compound 9987) is a small-molecule allosteric inhibitor that specifically inhibits the Tyr phosphatase activity of EYA2 with IC50 of 3.1 uM (Eya2 ED), but not other Eya family members. |
| PC-72451 |
NCGC00378430
SIX1-EYA2 inhibitor
|
NCGC00378430 (Compound 8430) is a novel small molecule compound that reduces the SIX1/EYA2 interaction in vitro with IC50 of 52 uM in the Alphascreen assay. |
| PC-72326 |
TK-453
SHP2 inhibitor
|
TK-453 (TK453) is a potent, selective SHP2 allosteric inhibitor with IC50 of 18.76 and 179 nM for SHP2-WT and SHP2-E76K, respectively. |
| PC-72034 |
PTPN22 inhibitor L-1
PTPN22 inhibitor
|
PTPN22 inhibitor L-1 (PTPN22-IN-1) is a selective, competitive small molecule inhibitor of PTPN22 with IC50 of 1.4 uM, Ki of 0.5 uM, 7- to 10-fold selectivity for PTPN22 over 16 similar PTPs. |
| PC-72033 |
CNBDA
SHP2 inhibitor
|
CNBDA is a novel selective Src homology phosphotyrosine phosphatase 2 (SHP2) inhibitor with IC50 of 5 uM, 25-fold selectivity over SHP1. |
| PC-38186 |
IACS-15414
SHP2 inhibitor
|
IACS-15414 (IACS 15414) is a potent, selective, orally bioavailable SHP2 inhibitor with IC50 of 122 nM. |
| PC-38184 |
SBI-4668
SHP2 inhibitor
|
SBI-4668 (SBI-668) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.73/1.8 uM for Wt SHP2/SHP2-E76K, 13-fold selective over PTP1B and 73-fold selective over STEP. |
| PC-38183 |
SBI-2130
SHP2 inhibitor
|
SBI-2130 (SBI 2130) is a novel furanylbenzamide molecule inhibitor of both WT and oncogenic SHP2 with IC50 of 0.22/5.0 uM for Wt SHP2/SHP2-E76K. |
| PC-38181 |
RMC-4630
SHP2 inhibitor
|
Vociprotafib (RMC-4630) is a potent and selective inhibitor of SHP2, a central node in the RAS signaling pathway. |
| PC-38180 |
TNO155
SHP2 inhibitor
|
Batoprotafib (TNO155) is a highly potent, selective, orally active, and allosteric SHP2 (PTPN11) inhibitor with IC50 of 11 nM. |
| PC-38070 |
IACS-13909
SHP2 inhibitor
|
IACS-13909 (IACS13909) is a potent, and selective allosteric inhibitor of SHP2 with IC50 of 15.7 nM (hSHP2 full length), Kd of 32 nM (ITC). |
