DJ001 | PTPσ inhibitor | Probechem Biochemicals

Chemical Structure : DJ001

CAS No.: 2161305-12-8

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DJ001 (DJ-001, DJ 001, Compound 5483071)

货号: PC-73052Not For Human Use, Lab Use Only.

DJ001 (DJ-001, UCLA 5483071) is a highly selective, allosteric protein tyrosine phosphatase-sigma (PTPσ) inhibitor with IC50 of 1.5 uM.

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5 mg	￥1980	In stock
10 mg	￥2980	In stock
25 mg	￥4780	In stock
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生物&药学活性

DJ001 (DJ-001, UCLA 5483071) is a highly selective, allosteric protein tyrosine phosphatase-sigma (PTPσ) inhibitor with IC50 of 1.5 uM.
DJ001 displays no inhibitory activity against 20 other phosphatases, with only modest inhibitory activity against Protein Phosphatase 5.
DJ001 antagonizes PTPσ via unique non-competitive, allosteric binding.
DJ001 suppresses radiation-induced hematopoietic stem cells (HSCs) apoptosis via activation of the RhoGTPase, RAC1, and induction of BCL-XL.
DJ001 promoteds HSC regeneration, accelerates hematologic recovery, and improves survival in irradiated mice.

物理化学性质&存储条件

分子量	268.272
分子式	C15H12N2O3
外观性状	Solid
CAS No.
储存条件	固体粉末 -20°C 12 个月; 4°C 6 个月	配置液 -80°C 6 个月; -20°C 6 个月
Shipping
Solubility	10 mM in DMSO
Chemical Name/SMILES	(Z)-3-((3-nitrophenyl)amino)-1-phenylprop-2-en-1-one

参考文献

1. Zhang Y, et al. Nat Commun. 2019 Aug 14;10(1):3667.

DJ001 (DJ-001, DJ 001, Compound 5483071)

生物&药学活性

物理化学性质&存储条件

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DJ001 (DJ-001, DJ 001, Compound 5483071)

生物&药学活性

物理化学性质&存储条件

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